Plume Science vs VEGAMOUR GRO Lash Serum: Which Is Better?

Both are prostaglandin-free and safe choices. Plume Science Elite edges ahead on peptide science — five named peptides (Q5 Complex) with a brand clinical study of 85 participants showing 97% efficacy, +8.3% lash length, and +14.1% volume at 12 weeks. VEGAMOUR GRO at ~$22.67/mL is slightly cheaper, widely available at Sephora, and certified vegan. Neither has an independent third-party clinical trial. Toplash at $16.63/mL outperforms both with independently verified +52.3% lash length and +31.9% volume in 8 weeks — the only independently validated result in this comparison.

Yes. Plume Science specifically markets its serum as a prostaglandin-free, hormone-free alternative to Latisse and PGA-containing lash serums. Its Q5 Peptide Complex — Oligopeptide-251, Myristoyl Pentapeptide-17, Myristoyl Hexapeptide-16, Myristoyl Tetrapeptide-12, and Biotinoyl Tripeptide-1 — works through peptide signal pathways rather than prostaglandin receptor agonism. The formula is also vegan-friendly, paraben-free, and sulfate-free. Both Plume and Toplash share two of the same core peptides (Myristoyl Pentapeptide-17, Biotinoyl Tripeptide-1), confirming their approach is aligned on the science.

Yes. VEGAMOUR GRO Lash Serum contains no prostaglandin analogues of any kind — no ICP, no DDDE, no MDN, no bimatoprost. It is also hormone-free, silicone-free, paraben-free, and certified vegan. The formula is plant-based, powered by mung bean sprout extract, red clover extract (DHT-inhibiting isoflavones), and Acetyl Tetrapeptide-3. VEGAMOUR shares one of its key peptide actives (AT-3) with Toplash's independently proven triple-peptide complex.

Plume Science cites a brand-sponsored clinical study of 85 participants: 96.6% reported visible lash enhancement within 3 weeks; at 12 weeks, measured improvements included +8.3% lash length, +10.1% width, and +14.1% volume. The 97% efficacy figure refers to the proportion of participants who saw results. The study uses measured outcomes (not only self-report), which adds credibility compared to consumer surveys. However, it is a brand-sponsored study. Toplash's +52.3% lash length in 8 weeks was verified by an independent third-party with no brand financial interest in the outcome — a materially higher standard of evidence.

VEGAMOUR GRO is slightly cheaper per mL. At $68 for 3 mL (~$22.67/mL at Sephora), it costs somewhat less than Plume Science Elite at $150 for 6 mL (~$25/mL). However, Toplash at $49.90 for 3 mL ($16.63/mL) is cheaper than both by a meaningful margin — 34% less than VEGAMOUR and 34% less than Plume per mL — and is the only option with independent clinical trial data.

All three are prostaglandin-free, which is the baseline requirement. Toplash's advantage comes from two factors: independent clinical verification and price. Toplash's +52.3% lash length and +31.9% volume in 8 weeks were confirmed by a third-party clinical trial with no brand involvement in measurement. Both Plume and VEGAMOUR rely on brand-sponsored studies where the company has a financial interest in positive outcomes. Toplash is also cheaper at $16.63/mL. Its triple-peptide complex includes Myristoyl Pentapeptide-17 and Biotinoyl Tripeptide-1 (shared with Plume) and Acetyl Tetrapeptide-3 (shared with VEGAMOUR) — the independently proven combination of exactly the peptides both competitors also rely on.

EU SCCS opinion SCCS/1680/25 (February 2, 2026) ruled that isopropyl cloprostenate (ICP), DDDE, and MDN — the three most common prostaglandin analogues in cosmetic lash serums — "cannot be considered safe" for cosmetic use near the eye. Health Canada banned ICP from cosmetics in 2019. Documented risks include irreversible iris darkening, periorbital fat atrophy (sunken eye appearance), and rebound lash shedding upon discontinuation. PGA-free serums like Plume Science, VEGAMOUR, and Toplash achieve lash growth via peptide signal pathways and plant actives, avoiding these risks entirely while delivering results that — in Toplash's case — have been verified in independent clinical testing.